Recombinant proteins are widely used to treat disease but the inherent instability of some proteins severely undermines their potential. At Cuboid Bio, we’re using PODS®, a natural mimetic protein depot technology, to harness the characteristic behaviours of mononuclear phagocytes to actively deliver protein drugs in order to treat solid cancers more effectively.
The remarkable microscopic cubes seen in this image are PODS® protein crystals that have been generated using a natural mimetic technology. PODS® stabilize embedded cargo proteins against the degradative effects of chemicals, UV and proteases. In storage, PODS® crystals are stable for years, even at high ambient temperatures. When in use, PODS® crystals provide a steady stream of bioactive proteins over a period of weeks.
PODS® technology expands the possibilities for proteins across many therapeutic applications.
If your therapeutic program is hampered by protein instability, we can probably help. Please get in touch