Reprogramming Monocytes to Beat Cancer
Monocytes play a pivotal role in the tumour microenvironment. These amazing cells have been difficult to harness. At Cuboid Bio, we’re using PODS®, natural mimetic protein depots, instead of DNA and RNA, to reprogram monocytes for immunotherapy of cancers.
Discover PODS®
The remarkable microscopic cubes seen in this image are PODS® protein blocks that have been generated using a natural mimetic technology. PODS® stabilize embedded cargo proteins against the degradative effects of chemicals, UV and proteases. PODS® are ingested by monocytes and remain bioactive to provide a steady stream of bioactive proteins, such as pro-inflammatory IL-2, over a period of weeks.
The origin of PODS®
PODS are a natural mimetic of a protein that evolved to provide stability to other cargo proteins to environmental insults, such as UV.
PODS® application areas
Address challenging protein pharmacokinetics. Locally administered or disease targetted
PODS® transforms protein delivery. If you are interested in using PODS® in your work, please get in touch.
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We are focusing on the treatment of cancer. PODS® technology also expands the possibilities for proteins across many therapeutic applications.